Nitric oxide activates cyclooxygenase enzymes.
نویسندگان
چکیده
منابع مشابه
Nitric oxide synthesis and nitric oxide synthase enzymes
Worldwide osteoarthritis (OA) affects more than 9.6% of men and 18% of women older that 60 years. Treatment for OA often requires chronic use of selective or nonselective nonsteroidal antiinflammatory drugs (NSAIDs), which have been associated with gastrointestinal and cardiovascular complications. An increased risk for upper gastrointestinal bleeding with NSAIDs alone and when combined with lo...
متن کاملInducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2.
Cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) are two major inflammatory mediators. Here we show that iNOS specifically binds to COX-2 and S-nitrosylates it, enhancing COX-2 catalytic activity. Selectively disrupting iNOS-COX-2 binding prevented NO-mediated activation of COX-2. This synergistic molecular interaction between two inflammatory systems may inform the developme...
متن کاملS - Nitrosylates , and Activates Cyclooxygenase - 2 Inducible Nitric Oxide Synthase Binds
http://www.sciencemag.org/cgi/content/full/310/5756/1966 version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/cgi/content/full/310/5756/1966/DC1 can be found at: Supporting Online Material found at: can be related to this article A list of selected additional articles on the Science Web sites http:/...
متن کاملNitric Oxide Amplifies Cyclooxygenase-2 Expression
Interleukin 1 and nitric oxide (NO) from infiltrating macrophages and activated mesangial cells may act in concert to sustain and promote glomerular damage. To evaluate if such synergy occurs, we evaluated the effect if IL-1 b and NO on the formation of prostaglandin (PG) E 2 and cyclooxygenase (COX) expression. The NO donors, sodium nitroprusside and S -nitrosoN -acetylpenicillamine, alone did...
متن کاملCyclooxygenase-inhibiting nitric oxide donators for osteoarthritis.
Nonsteroidal anti-inflammatory drugs (NSAIDs) remain the most commonly used medications for the treatment of the symptoms of many chronic inflammatory diseases, including osteoarthritis. Unfortunately, the toxicity of NSAIDs substantially limits their long-term use. Some newer NSAIDs, namely selective cyclooxygenase (COX)-2 inhibitors, exhibit greater gastrointestinal safety, and concomitant us...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1993
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.90.15.7240